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One technological solution involves the use of a GRAS strain, Lactobacillus paracasei , engineered to express exenatide

The net result

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The resulting formulation shows sustained-release kinetics, markedly enhanced cellular uptake, and prolonged ocular surface residence time, thereby effectively ameliorating alkali burn-induced corneal injury

Moreover, it boosts endothelial permeability by reducing the levels of Coll5a1, Lama4, and Sparc in the extracellular matrix and cytoskeleton [39]

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