The limitations of this work are that we included RCTs, non-RCTs, and observational studies, which may lower the overall quality of evidence of the included studies
Previously, we have explained how IO&NS and NF-B and their associated pathways may explain the central and peripheral symptoms of CFAS-D (3, 15, 16, 23, 36, 63)
10.3168/jds.2016-11761 250 Van Der SteegW
Baar MP, Brandt RMC, Putavet DA, et al
In addition, metformin-induced AMPK activation promotes activation of the SIRT1/PGC-1 pathway suggesting interplay between AMPK and SIRT1/PGC-1 in the neuroprotective effect of metformin
In this review, we aim to provide a deeper theoretical foundation and empirical support for using topiramate to treat migraines