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Anti-IGF-1 receptor (IGF-1R) monoclonal antibodies (mAbs) were developed for clinical use in treating advanced stage cancers 22,23,24 , including Ganitumab, which remains under investigation as a combination therapy in clinical trials targeting Rhabdomyosarcoma (NCT03041701) and Ewing Sarcoma (NCT02306161), for which it recently received orphan drug status
Emerging research highlights the role of Mn beyond individual organ systems, revealing coordinated interactions between the liver, intestines, and brain
Katiyar, A
The optimal dosing, administration route, and cycling protocol for humans remain uncertain
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