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While pharmaceutical doses of GLP-1 can force appetite suppression (which is why semaglutide often causes nausea), GIP activates the pathway these neurons are designed for

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GIP receptor activation complements these effects by promoting insulin secretion, while potentially improving insulin sensitivity in peripheral tissues and influencing lipid metabolism and energy expenditure, though these additional effects have more limited human data

Systemic symptoms such as headache, somnolence, and a decrease in motor activity, as well as hypophagia (a decrease in food intake), which leads to loss of body mass, may also accompany fever [2,3]