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Despite the promising therapeutic potential of azelaic acid in melasma, however due to limited water solubility and poor skin permeability, its conventional topical formulations have been fabricated in higher doses (10%20%) to achieve the desired clinical outcome (Sieber and Hegel, 2014

The US National Kidney Foundation did not recommend routine administration of L-carnitine to subjects undergoing dialysis yet encouraged the development of trials in patients with select symptoms that do not respond to standard therapy, i.e., persistent muscle cramps or hypotension during dialysis, severe fatigue, skeletal muscle weakness or myopathy, cardiomyopathy, and anemia requiring large doses of erythropoietin (74, 75)

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Travedi, M

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