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Although extensive research work has still to be performed to define in precise terms the multiple relationships that have some evidence, the main facts may be, however, considered here and summarized

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noted reduced expression of the GHR in the kidneys of 5/6 nephrectomized animals, which was associated with elevated pro-inflammatory cytokines, suggesting that GH-insensitivity in uremia is a general phenomenon and not restricted to the liver and growth plates ( vide supra ) [174]

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Kane DA, Anderson EJ, Price JW, Woodlief TL, Lin CT, Bikman BT, et al