PRODUCT FACTS
Amsterdam: Elsevier/North Holland Biochemical Press
The molecular mechanism of action involves binding to the insulin receptor-a receptor tyrosine kinase-triggering downstream PI3K/Akt and MAPK cascades that promote GLUT4 translocation, glycogen synthesis, lipogenesis, protein synthesis, and cellular growth
Research suggests doing so can reduce post-meal glucose spikes by as much as 75%, he says
In the latest JAMA Medical News podcast, Jennifer Abbasi interviews Rita Kalyani, MD, about investigational therapies including retatrutide, a triple agonist showing high efficacy for glycemic control and weight loss, and new oral options like orforglipron
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