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These questions havent been conclusively answered
According to research, Breg activity can be inhibited by downregulating the expression of the thioredoxin (TXN) gene, which encourages the development of pro-inflammatory B cells and causes systemic inflammation (85)
10.2131/jts.48.487 116 SunZ.ShiK.YangS.LiuJ.ZhouQ.WangG.et al (2018)
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