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All gastrointestinal adverse events (GI AEs) were mild, except for one participant who reported two moderate events (nausea and vomiting) and discontinued treatment after the third administration

These effects explain why GLP-1 receptor agonists are useful for both type 2 diabetes and chronic weight management

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The risk of ketotic hyperglycemia did not increase in the aforementioned meta-analysis (56)

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Immune cell metabolic reprogramming and antitumor activity Moreover, the tumor environment imposes metabolic constraints on tumor-infiltrating lymphocytes (TILs), impairing their ability to slow tumor progression [82]