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they imitate a hormone and target brain areas that govern appetite and food intake

In this perspective, we discuss evidence that may support potential adverse effects of intermittent fasting on cardiovascular health through the loss of lean mass, circadian misalignment and poor dietary choices associated with reward-based eating

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If side effects persist and remain intolerable despite extended up-titration, a lower maintenance dose may be considered to support adherence and reduce the risk of treatment discontinuation [66]

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18 March 2025