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Several studies of centenarians (humans who have lived to be over 100 years old) in various countries, including Poland, Italy, and Denmark, have found very high levels of glutathione in their cells
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could modulate fibril formation and exacerbate -synuclein expression in the colon ( Akkermansia protein secretome, which dysregulates calcium homeostasis, leading to the promotion of calcium uptake in the mitochondria of entero-endocrine cells, triggering the formation of reactive oxygen species and subsequent -synuclein phosphorylation, aggregation, and deposition in vitro ( in vitro evaluation, it highlights previously unknown functions of distinct microbes in influencing the formation of pathogenic fibrils (Figure 2A)
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