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Retatrutide is a single engineered peptide designed to activate the GLP-1, GIP, and glucagon receptors

2), with the complete dataset cataloged in Supplementary Table 4

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Caffeine is acidic and relaxes the esophageal sphincter, which can worsen acid reflux

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However, it is rendered ineffective when evaluating possible toxicity due to multiple ingestions over time, when time of ingestion is unknown, or when altered metabolism occurs