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In some embodiments, the steady state concentration of an active agent released from a controlled-release otic formulation described herein is from about 20 to about 50 times the steady state concentration of an active agent released from a formulation that is not a controlled-release otic formulation

6s) 84,85 , which is an indicator of mitochondrial workload

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PMID 38753454

New legislation at the state and federal level (Medicare) limits the co-pay that can be charged, but this does not address list prices

and 0 indicated no movement seen, severe granularity, non-viable [37,38,39] as observed under bright field at 1040 magnification with an inverted microscope (Nikon Phase Contrast 2, LDW 0.52