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This modification enhances NNTs affinity for its substrate NADP+, promoting NADPH synthesis, maintaining ironsulfur cluster homeostasis, lowering intracellular ferrous iron levels and lipid peroxidation, and thereby protecting tumor cells from ferroptosis (118)

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TB-500 upregulates VEGF and actin-binding proteins, whereas BPC-157 improves endothelial repair and vascular stability

The R72 variant is found primarily at higher geographical latitudes and has been described as metabolically disadvantageous, as it positively correlates with BMI and the susceptibility to diabetes 38

Jurado-Flores et al., 2021)

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