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They work through different brain pathways to promote satiety

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The seven sirtuin isoforms have distinct subcellular localisations and substrate specificities with broad regulatory reach: SIRT1 (nuclear/cytoplasmic) regulates gene expression, insulin signalling, and stress responses via deacetylation of p53, NF-B, FOXO, and PGC-1

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This allows for multiple withdrawals from the same vial without the need for refrigeration