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The difference reflects tirzepatide's dual GLP-1 plus GIP receptor mechanism: the added GIP pathway enhances appetite suppression and fat metabolism beyond what GLP-1 alone provides

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Announced by Novo Nordisk on January 17, 2025, the randomized, double-blinded, parallel-group, placebo-controlled STEP UP trial evaluated the efficacy of semaglutide 7.2 mg to semaglutide 2.4 mg (Wegovy) and placebo in more than 1400 adults with obesity and without type 2 diabetes (T2D)

Metabolic benefits beyond weight loss Weight loss is the headline, but both medications produce metabolic improvements that extend far beyond the number on the scale

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