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In a recent review (2018) by the famous Cochrane Institute, it was reported that studies which had been published on this topic only provided very low-quality evidence that oral B12 is as efficacious as intramuscular B12

The injection is given into the fatty subcutaneous tissue (often in the abdomen, thigh, or upper arm)

We recommend planning your experiments within this timeframe to ensure you're always working with a maximally effective compound

[2] Folic acid is relatively nontoxic in man

We have several ways to make this treatment comfortable, including relaxing medications and nitrous oxide (laughing gas)

Pradeep Kumar: nothing to disclose