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The enzymatic activity of prolyl 4-hydroxylase subunit alpha 1 (P4HA1), a procollagen-proline, 2-oxoglutarate 4-dioxygenase, is crucial for collagen polypeptide chain folding into stable triple-helical molecules and consequently for ECM deposition [23]

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Introduction Nanoparticles (NPs) are nanoscopic particles ranging from 1 to 100 nm, comprising materials such as carbon, metals, metal oxides, polymers and so on (Lee and Jun 2019