Conclusion: Long-term randomized placebo-controlled trials with larger sample sizes are needed to provide stronger evidence on the long-term efficacy and safety of semaglutide for obesity treatment in PWS as well as explore the potential synergistic effects of GLP-1 RA treatment combined with other therapeutic interventions
[57] showed that oxytocin administration into the BLA impaired acquisition of context-conditioned fear, demonstrating a neuro-modulatory role for the neuropeptide
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Consistent with the changes of c-fos levels in immunoblot analyses, the immunofluorescence results for c-fos in the TNC showed that the number of c-fos immunoreactive cells in the exendin(939) treated group (CM + Exe(939), 72.33 14.95) was higher than that of sham group (39.83 13.23) (Fig
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VK2735 Continuing on with the GLP-1 and GIP agonist theme, VK2735 from Viking Therapeutics is another potential candidate in the pipeline