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Nuclear factor erythroid-2-related factor-2 (Nrf2) is an important antioxidant regulator that promotes the HO-1, GSH, and GPx4 expression in the downstream, eliminates ROS accumulation in the liver, and reduces malondialdehyde (MDA) levels (36)

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TB-500 contains the parent molecules actin-binding region, but shared sequence does not establish equivalent behaviour

the effects of this cascade are dose-dependent (161)

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p = 0.041) by the main analysis and other MR approaches (Figure 3)