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For mild cases or other GI conditions, starting at even lower doses (0.125 mg weekly via precise syringe measurement from a 2.5mg/mL vial) and titrating over eight to twelve weeks per level can improve tolerability
A 2025 review published in Obesity Pillars, authored by registered dietitians and nutrition researchers, concluded that fiber and probiotic supplements can help reduce constipation and improve stool consistency in GLP-1 users, and identified fiber as one of the key nutritional priorities for people on these medications
These may arise from exogenous as well as endogenous sources (Fig