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Its anti-inflammatory qualities also help reduce inflammation and redness, giving the skin barrier a more balanced and healthy appearance (3)

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Furthermore, Nrf2/HO-1 interacts with the NF-KB and JAK-STAT pathways in various contexts: Nrf2/HO-1 can reduce NF-KB phosphorylation and thereby dampen inflammation, whereas proinflammatory cytokines such as TNF- and IL-6, released following NF-KB activation, upregulate HO-1 in a feedback loop (125, 129)

Other physiologic variables that influence the production of melanin include estrogen and progesterone

An example is an intrauterine device (IUD) such as levonorgestrel (Kyleena, Mirena, others)

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