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The force of water hitting the delicate lyophilized cake can shear peptide bonds and denature the compound

Furthermore, the review emphasize the need for further development of nanotechnology-based antioxidant treatments, including innovation in nanoparticle design, stability of nanoparticles, and targeting mechanisms

Any correction protocol that exfoliates and treats without restoring the barrier leaves the tissue exposed to exactly the kind of environmental aggression that triggered the pigmentation in the first place