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The SURPASS clinical trial program showed mean heart rate increases of approximately 2 to 4 beats per minute

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Gastrointestinal side effects typically improve significantly within the first 8-16 weeks of treatment

Renal function should be monitored in patients with renal impairment or when experiencing severe gastrointestinal adverse effects that could lead to dehydration and acute kidney injury

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Key Takeaway: The primary interaction between these drugs is pharmacokinetic, meaning Zepbound changes how the body moves the antibiotic through the system, rather than changing the antibiotics chemical structure