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4.4.4 Integrative perspective: convergent and divergent metabolic fates of amino acids in DKD The preceding sections delineate distinct metabolic trajectories for aromatic amino acids (AAA), branched-chain amino acids (BCAA), and sulfur-containing amino acids (SAA) within the gut-liver-kidney axis

doi: 10.1016/0006291X(89)917579 168 MiyataAJiangLDahlRDKitadaCKuboKFujinoMet al

This metabolic shift is highly problematic because anaerobic glycolysis produces only a fraction of the ATP generated by aerobic respiration, and it creates toxic byproducts in the process