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Like the GSH term classifiers, RF models with 550 CCLE transcriptomic PCs and corresponding metabolomic correlations as features were trained for the annotation of genes related to 2-oxoglutarate, glutamate, and carnitine

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SFN increased the expression of GCLC and GCLM mRNA and GSH/GSSG ratio in both healthy primary neutrophils and periodontitis patients mimicking the effect of SFN on GSH/GSSG seen in differentiated HL60 cells

and (3) it triggers pyroptosis through activating the protein gasdermin D, hence initiating neuro-inflammatory signals within the brain parenchyma (10, 48)

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