Due to a short plasma half-life of native GLP-1, several synthesized GLP-1 receptor agonists (RAs) were developed for type 2 diabetes mellitus (DM) treatment
Some telehealth providers offer compounded versions (e.g., semaglutide), which may be cheaper but lack FDA approval
Doctors need to watch patients on GLP-1 for signs of gastroparesis
The mechanism behind cold sensations on tirzepatide is likely multifactorial
In support of this notion, subcutaneously administered LUXendin645, an Ex9based GLP1 receptor antagonist, has been demonstrated to have an overlapping distribution with PPG axons in the arcuate nucleus (Ast et al., 2020)
Better Blood Pressure: Some individuals experience slight improvements in blood pressure as a result of weight loss and better blood sugar control