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Pigo-Zajc D, Mazurek M, Maziarz M, Ochieng Otieno M, Martinez-Useros J, Maecka-Massalska T, Powrzek T

Insulin resistance is what happens when the cells in your muscles, fat, and liver don't respond well to insulin and can't use glucose (i.e., sugar) from your blood for energy, per the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

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GLP-1 receptor agonism is associated in the research literature with modulation of satiety signaling and energy expenditure, underpinning much of the weight reduction focus in Retatrutide study designs