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Among the 101 participants receiving the highest 4.5 mg/week dose, the most frequently reported side effects included: Indigestion: 4% Headache: 7% Loose stools: 7% Vomiting: 8% Allergic reactions: 10% Fatigue: 20% Constipation: 21% Injection site reactions: 43% Nausea: 47% Serious side effects in this phase 2 trial occurred in 2% to 7% of the cagrilintide groups, compared to 4% in the liraglutide group and 3% in the placebo group

192 These findings suggest that lysosomal pathways may play a critical role in regulating acinar cell death during AP, a possibility that warrants further investigation

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Receptor-mediated activation of gastric vagal afferents by glucagonlike peptide1 in the rat

Governance arrangements must be implemented specifically around accountability for health professionals, with a focus on training and evaluation of quality of practice