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What is the difference between Category 2 and FDA approval

A few of the studies people point to: Appetite and body fat: a 12-week randomized, placebo-controlled trial in BMC Complementary Medicine and Therapies found yerba mate supplementation reduced body fat and waist-to-hip ratio without notable side effects

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Nevertheless, the combination of L-leucine, creatine, and L-Carnitine potentiated the development of muscle mass and increased strength in older adults supplemented with the L-Carnitine-combination product, likely through a common mechanism, such as promoting increase protein synthesis, increasing branched amino acid bioavailability, and decreasing protein degradation [43]

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