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The 4 distinct features in positive correlation with HbA1c reduction were defined as positive microbial signatures, whereas the 13 distinct features in negative correlation were defined as negative microbial signatures in GLP-1 RA treatment of T2D patients

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In its preclinical pitch deck, ASC35 outperformed once-weekly tirzepatide by about 71% in diet-induced obese mice and showed a half-life roughly six times longer than tirzepatide in non-human primates

doi: 10.1007/s13311-015-0375-5

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