These are not the therapeutic targets of GLP-1 or GLP-1/GIP therapy
Prescribers should document the clinical rationale for compounding, explain to patients that the formulation is custom-prepared, and select accredited compounding pharmacies to minimize quality variability
[2] Disruption at any stage of this tightly regulated system, whether through impaired insulin secretion, reduced tissue responsiveness, excessive glucose production by the liver, or hormonal imbalance, can result in sustained hyperglycemia
10.1038/srep31853 Sci
For instance, less severe loss of fat has been reported in patients with exon 11 LMNA pathogenic variants which affects only lamin A protein (107)
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