For example, GLP-1 RAs have been shown to help in heart failure and also to have beneficial effects on heart rhythm.[ref] Cognitive function: Studies are showing positive effects on cognitive function and possibly reduced (or delayed) dementia with GLP-1s
Before we discuss these drugs further, a quick reminder that it's always best to seek medical advice from healthcare providers about what may or may not be right for you
adults without diabetes using these drugs
Better markers include: A1c / glycemic variability (for people with diabetes or prediabetes risk) blood pressure, triglycerides, HDL, ApoB (when available) liver fat / MASLD risk (when assessed) waist circumference / visceral adiposity risk markers functional outcomes: energy, sleep, appetite control, physical capacity GLP-1 agents have extensive data on meaningful clinical endpoints and safety signals across large populations
We emphasize the importance of medical supervision to optimize outcomes and ensure patient safety
Figure 3 shows that, while there were no or small differences in discontinuation rates between subgroups according to status of ASCVD, chronic kidney disease and heart failure among users of GLP-1 receptor agonists, discontinuation rates were higher among those with normal weight vs other weight categories
