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Abstract Pituitary tumors, that origin from excessive proliferation of a specific subtype of pituitary cell, are mostly benign tumors, but may cause significant morbidity in affected patients, including visual and neurologic manifestations from mass-effect, or endocrine syndromes caused by hormone hypersecretion

The de-succinylation of H3 promotes chromatin condensation and efficient DSB repair

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Activation of POMC neurons leads to the release of alpha-melanocyte-stimulating hormone (-MSH), which subsequently binds to the melanocortin 4 receptor in the paraventricular nucleus of the hypothalamus and triggers appetite-inhibiting signaling cascade

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