Recently, C5a receptor blockade was found to be protective in a murine AAV disease model (135) and steroid sparing in patients with AAV (136)
It is primarily used to treat sexual dysfunction in both men and women
Perazella MA, Rosner MH (2022) Drug-induced acute kidney injury
The continuous dose of 2 mg/kg/day for 28 days is consistent with sub-chronic exposure models designed to evaluate oxidative stress and inflammation [25, 26]
Koal, T., Klavins, K., Seppi, D., Kemmler, G
Ecotoxicol Environ Saf 107:260268 Rabus R, Boll M, Heider J, Meckenstock RU, Buckel W, Einsle O, Ermler U, Golding BT, Gunsalus RP, Kroneck PMH, Krger M, Lueders T, Martins BM, Musat F, Richnow HH, Schink B, Seifert J, Szaleniec M, Treude T, Ullmann GM, Vogt C, von Bergen M, Wilkes H (2016) Anaerobic microbial degradation of hydrocarbons: from enzymatic reactions to the environment