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Introduction Fetal growth restriction (FGR) is a severe condition during pregnancy, where the fetus does not grow according to its potential as a result of an adverse uterine environment (Kingdom and Smith, 2000)

Protein expression was detected using an enhanced chemiluminescence (ECL) kit (NCM Biotech, Suzhou, China) and a ChemiDoc XRS System (Bio-Rad, CA, USA)

For topical routines, consistent use over several weeks is more realistic than expecting results after one or two applications

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