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Because ALOXs are a nonheme iron-containing enzymes, the presence of iron significantly increases their oxidative activity, and the subsequent generation of PLOOH continues to react with Fe 2+ , generating new lipid radicals
doi: 10.2147/IJN.S334965 214 LanXHanXLiQWangJ
This timeline is built from the trial record primarily the Phase 2 monotherapy dose-finding study (Lau et al., 2021) and the REDEFINE Phase 3 combination trials (Aronne et al., 2025
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When maintained at controlled concentrations, reactive species play a crucial role in various physiological processes, including cellular signaling, phagocytosis, and regulation of vascular tone [8,11,12]
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