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Andrew Kraftson, MD, the director of the weight navigation program at Michigan Medicine in Ann Arbor, agrees that skipping a single dose is unlikely to quickly alleviate any gastrointestinal side effects

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Dehydration is a particular concern, as reduced food intake often means reduced fluid intake, and gastrointestinal side effects such as vomiting or diarrhoea can further deplete fluid and electrolyte balance

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In other words, the decrease in depression symptoms might be independent of any change in BMI