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Similar content being viewed by others Introduction Autism spectrum disorder (ASD) is a complex neurodevelopmental condition affecting a substantial portion of the population, with an estimated prevalence of approximately 1 in 36 children in the United States, a figure that continues to grow annually (Maenner et al

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High levels of thioredoxin-interacting protein (TXNIP) in beta cells may inhibit the ability of thioredoxin in the peroxiredoxin-thioredoxin system to detoxify H 2 O 2 (Ovalle et al

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doi: 10.1146/annurev-pharmtox-011112-140320

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J Neural Transm (Vienna) 129(8):10771089 Funakoshi H, Kanai M, Nakamura T (2011) Modulation of tryptophan metabolism, promotion of neurogenesis and alteration of anxiety-related behavior in tryptophan 2,3-dioxygenase-deficient mice

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As healing progresses, physical therapy becomes a central part of rehabilitation, helping to restore range of motion, rebuild muscle strength, improve balance and stability, and reinforce proper movement patterns

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