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Description

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CaMKK2 is essential for the activation of mitochondria-localised AMPK, and genetic deletion of either Camkk2 or the AMPK catalytic subunits ( Prkaa1 and Prkaa2 ) results in reduced PGC-1 expression and suppression of mitochondrial respiration [43, 127,128,129,130]

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Those criteria exist because the trials that earned approval enrolled patients who met them

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