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Litwin, T., Duek, P

Even though animal models show benefits from melatonin supplementation on depressive-like behavior, clinical evidence is inconsistent vis--vis prophylactic or therapeutic benefits of melatonin or melatonin agonists in depression

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doi: 10.3389/fimmu.2026.1758379 Received 01 December 2025 Revised 05 March 2026 Accepted 05 March 2026 Published 28 April 2026 Volume 17 - 2026 Edited by Varun Sasidharan Nair, Italian Institute of Technology (IIT), Italy Reviewed by Mahmoud Abdelrahman Alkabbani, Egyptian Russian University, Egypt Lingjie Meng, Zunyi Medical University, China Updates Copyright 2026 Sivalingam