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Novel small molecule agonist of TGR5 possesses anti-diabetic effects but causes gallbladder filling in mice

In addition, betaine significantly upregulated the protein expression of AMPK (AMP-activated protein kinase), FGF10 (fibroblast growth factor 10), and ATGL (adipose triglyceride lipase) and suppressed hepatic lipid accumulation in mice, suggesting that betaine prevents NAFLD via FGF10/AMPK signaling pathway ( Betaine supplementation was observed to decrease histopathological alterations and serum markers of hepatotoxicity in animal models of acute and chronic non-alcoholic liver injury

10.1016/j.jplph.2020.153273 [DOI] [PubMed] [Google Scholar] 24.Gong AD, Lian SB, Wu NN, Zhou YJ, Zhao SQ, Zhang LM, et al

Metabolomic and lipidomic profiling of the spinal cord in type 2 diabetes mellitus rats with painful neuropathy

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