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Most providers use a "start low and go slow" approach called titration

A tight control is needed to adjust each enzymatic step to the cellular requirements because the whole pathway consumes energy and produces toxic/reactive compounds, notably sulfite and sulfide

One study in an XP population found therapeutic use of fluorouracil (5-FU) to be efficacious, particularly in the treatment of extensive lesions

doi: 10.1016/j.redox.2019.101179 29 JungMKasamatsuSMatsunagaTAkashiSOnoKNishimuraAet al

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The pharmacology is different enough that CagriSema results cannot be assumed to transfer to a tirzepatide pairing