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The highly prevalent GSTM1(0) is associated with more rapid CKD progression in the African American Study of Kidney Disease (AASK) trial participants [138]

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Nevertheless, no inhibitor has yet reached phase I clinical trials and further efforts are needed to circumvent all obstacles related to absorption, metabolism and various issues on pharmacokinetics in order to eventually achieve orally bioavailable drug candidates acting as cognitive enhancers in vivo

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