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Ultimately, the convergence of microbiome science, immunology, and precision neurology positions multimodal biomarkers as the cornerstone of next-generation early diagnostics and personalized intervention strategies in PD [200]

At the level of the colon the GLP-1-serotonin interaction may be reciprocal since serotonin or serotonin 5HT 1B receptor agonists also increase GLP-1 secretion from the enteroendocrine cells (18, 19)

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doi: 10.1126/science.aaw7894 146 BiselliEAgliariEBarraABertaniFRGerardinoADe NinnoAet al

127,128 Upregulation of DPP4 in type I pneumocytes may be a critical factor in MERS-CoV and SARS-CoV-2 infection severity (Figure 4)

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