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Semaglutide patients often have a slower start, particularly at the initiation dose

Supriya Rao, M.D., a board-certified physician in internal medicine, gastroenterology, obesity medicine, and lifestyle medicine based in Boston

Sugar alcohols in particular are prime offenders because they are poorly absorbed and ferment rapidly, which is why combining semaglutides slowed digestion with those sweeteners often produces severe bloating and prolonged discomfort

The First Wave: Older GLP-1 Medications Before semaglutide stole the spotlight, several other GLP-1 agonists were used primarily for diabetes management, with modest weight loss benefits

This includes physician offices, outpatient clinics, and hospital outpatient departments

At 10 mg per week, this covers three weeks