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In endomyocardial biopsies, higher burdens of mtDNA mutations are associated with reduced ejection fraction and worse outcomes ( 3.3 Oxidative stress and calcium overload Oxidative stress and calcium overload are tightly interconnected mechanisms of mitochondrial dysfunction in HF

Thymosin beta-4 is present in nearly all human and animal cells and plays a crucial role in various healing and regenerative processes

10.1007/s10620-023-08122-w [DOI] [PMC free article] [PubMed] [Google Scholar] 21.Liu Z, Zhang Y, Jin T, Yi C, Ocansey DK, Mao F

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EGCG (epigallocatechin gallate, a green tea polyphenol) disrupts the binding of HK2 to mitochondria, thereby impairing energy metabolism and inducing apoptosis (101)