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doi: 10.3389/fneur.2025.1653900 Received 27 June 2025 Accepted 16 October 2025 Published 05 December 2025 Volume 16 - 2025 Edited by Vitor Engracia Valenti, So Paulo State University, Brazil Reviewed by Irina Duff, Johns Hopkins Medicine, United States Sharath Kommu, Marshfield Clinic, United States Updates Copyright 2025 Tian, Zhang, Zhang, Ge, Luo, Zhang, Wang and Zhai