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Similarly, four weeks of chronic unpredictable mild stress in male mice reduces microglial KMO via corticosterone, increasing hippocampal KYNA and producing depressive-like behaviours that are rescued by nicotine-mediated 7nAChR activation [72]

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Functional enrichment analysis The Database for Annotation, Visualization, and Integrated Discovery function annotation tool ( was used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis on differentially expressed proteins (DEPs) [31]

10.1002/14651858.CD005355.pub5 61 KorompelisP.PiperiC.AdamopoulosC.DalagiorgouG.KorkolopoulouP.SepsaA.et al (2015)

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