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Most of these effects appeared during the dose escalation phase and resolved within the first 12 weeks

Thus, specific metal-based nanoparticle-based therapeutics have already been approved by the United States Food and Drug Administration (FDA) ( While the increasing need for novel drugs or drug-release systems has led to vast advancements in nanomedicine, some safety concerns exist (Liu et al., 2020a

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[16] Reduction in leptin levels are linked to greater food satiety

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